CircRNA_0084927 promotes colorectal cancer progression by regulating miRNA-20b-3p/glutathione S-transferase mu 5 axis

Figure 3 CircRNA_0084927 acts as a sponge of miRNA-20b-3p in colorectal cancer. A: CircRNA_0084927 (Circ_0084927) potentially acts as a sponge of miRNA-20b-3p (miR-20b-3p) in database; B: miR-20b-3p mimic could markedly reduce the luciferase activity of circ_0084927; C: miR-20b-3p inhibitor could markedly increase the luciferase activity of circ_0084927; D: circ_0084927 knockdown markedly increased the level of miR-20b-3p; E: Expression of miR-20b-3p in colorectal cancer (CRC); F: Correlation of circ_0084927 and miR-20b-3p. Data are presented as the mean ± SEM. ^aP < 0.05; ^bP < 0.01. Circ_0084927: CircRNA_0084927; MiR-20b-3p: MiRNA-20b-3p; NC: Negative control; CRC: Colorectal cancer; Normal: Adjacent normal tissues; Circ_0084927-WT: CircRNA_0084927 wild type; Circ_0084927-Mut: CircRNA_0084927 mutant; Sh-circ_0084927: Short hairpin circ_0084927 plasmid; Sh-NC: Short hairpin negative control plasmid.