Clinicopathological characteristics and longterm survival of patients with synchronous multiple primary gastrointestinal stromal tumors: A propensity score matching analysis

Table 4 Univariate and multivariate analysis of the clinicopathological factors for overall survival

Characteristics	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age in yr
≤ 65	Reference
> 65	1.665 (0.754-3.676)	0.207
Gender
Female	Reference
Male	1.099 (0.461-2.616)	0.832
Comorbidities
Absent	Reference
Present	1.061 (0.491-2.291)	0.881
Tumor location
Gastric	Reference		Reference
Non-gastric	4.428 (1.967-9.965)	< 0.001	3.812 (1.577-9.213)	0.003
Tumor size in cm		0.021		0.556
Length ≤ 5	Reference		Reference
5 < Length ≤ 10	2.279 (0.722-7.189)	0.160	1.381 (0.346-5.519)	0.648
Length > 10	4.159 (1.498-11.549)	0.006	2.070 (0.539-7.959)	0.290
Mitotic index, per 50 HPF		< 0.001		0.015
0-5	Reference		Reference
6-10	3.120 (0.913-10.669)	0.070	4.129 (0.963-17.707)	0.056
> 10	7.515 (3.045-18.548)	< 0.001	6.051 (1.762-20.778)	0.004
Surgical approach		0.684
Open	Reference
Laparoscopic	0.621 (0.213-1.815)	0.384
Endoscopic	0 (0-3.609E+275)	0.968
Blood transfusion
No	Reference		Reference
Yes	2.832 (1.312-6.113)	0.008	1.298 (0.547-3.082)	0.554
Intraoperative tumor rupture
No	Reference		Reference
Yes	5.094 (0.682-38.043)	0.113	3.264 (0.355-30.022)	0.296
Imatinib treatment
Yes	Reference		Reference
No	2.952 (1.113-7.831)	0.030	7.841 (2.677-22.693)	< 0.001
MGIST
Absent	Reference		Reference
Present	2.050 (0.889-4.726)	0.092	2.404 (0.830-6.966)	0.106

Bold values indicate P < 0.05. CI: Confidence interval; HPF: High power field; HR: Hazard ratio; MGIST: Multiple gastrointestinal stromal tumors.