Clinicopathological characteristics and longterm survival of patients with synchronous multiple primary gastrointestinal stromal tumors: A propensity score matching analysis

Table 3 Univariate and multivariate of the clinicopathological factors for progression-free survival

Characteristics	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age in yr
≤ 60	Reference		Reference
> 60	1.845 (0.953-3.571)	0.069	1.525 (0.740-3.143)	0.252
Sex
Female	Reference
Male	0.913 (0.460-1.809)	0.793
Comorbidities
Absent	Reference
Present	1.147 (0.606-2.172)	0.673
Tumor location
Gastric	Reference		Reference
Non-gastric	3.548 (1.847-6.818)	< 0.001	3.176 (1.526-6.607)	0.002
Tumor size in cm		0.001		0.035
Length ≤ 5	Reference		Reference
5 < Length ≤ 10	3.022 (1.117-8.179)	0.029	2.180 (0.716-6.642)	0.170
Length > 10	5.848 (2.359-14.499)	< 0.001	4.071 (1.375-12.052)	0.011
Mitotic index, per 50 HPF		< 0.001		0.001
0-5	Reference		Reference
6-10	4.094 (1.555-10.777)	0.004	4.108 (1.309-12.897)	0.015
> 10	7.859 (3.676-16.799)	< 0.001	6.577 (2.540-17.029)	< 0.001
Surgical approach		0.251
Open	Reference
Laparoscopic	0.449 (0.174-1.154)	0.096
Endoscopic	0 (0-1.006E+230)	0.961
Blood transfusion
No	Reference		Reference
Yes	2.176 (1.143-4.145)	0.018	1.569 (0.739-3.332)	0.241
Intraoperative tumor rupture
No	Reference		Reference
Yes	6.383 (1.524-26.726)	0.011	4.458 (0.863-23.015)	0.074
Imatinib treatment
Yes	Reference		Reference
No	0.584 (0.290-1.178)	0.133	4.608 (2.030-10.461)	< 0.001
MGIST
Absent	Reference		Reference
Present	2.091 (1.055-4.145)	0.035	2.431 (1.097-5.386)	0.029

Bold values indicate P < 0.05. CI: Confidence interval; HPF: High power field; HR: Hazard ratio; MGIST: Multiple gastrointestinal stromal tumors.