Clinicopathological characteristics and longterm survival of patients with synchronous multiple primary gastrointestinal stromal tumors: A propensity score matching analysis

Table 2 Surgical and postoperative pathological characteristics and treatment of the solitary gastrointestinal stromal tumors and multiple gastrointestinal stromal tumors of the entire cohort and after propensity score matching

Parameters	Entire cohort, before matching		P value	Propensity score matched cohort		P value
	SGIST, n (%)	MGIST, n (%)		SGIST, n (%)	MGIST, n (%)
All cases	942	41		164	41
Surgical approach			0.028			0.361
Open	458 (48.62)	27 (65.85)		94 (57.32)	27 (65.85)
Laparoscopic	255 (27.07)	11 (26.83)		43 (26.22)	11 (26.83)
Endoscopic	229 (24.31)	3 (7.32)		27 (14.63)	3 (7.32)
Blood transfusion			0.161			1.000
Yes	171 (18.15)	11 (26.83)		44 (26.83)	11 (26.83)
No	771 (81.85)	30 (73.17)		120 (73.17)	30 (73.17)
Tumor size (cm)			0.007			0.200
Length ≤ 5	575 (61.04)	15 (36.59)		74 (45.12)	15 (36.59)
5 < Length ≤ 10	239 (25.37)	16 (39.02)		41 (25.00)	16 (39.02)
Length > 10	128 (13.59)	10 (24.39)		49 (29.88)	10 (24.39)
Mitotic index (per 50 HPF)			0.009			0.715
0-5	724 (76.86)	27 (65.85)		101 (61.59)	27 (65.85)
6-10	127 (13.48)	4 (9.76)		24 (14.63)	4 (9.76)
> 10	91 (9.66)	10 (24.39)		39 (23.78)	10 (24.39)
Modified NIH risk			0.044			0.486
Very low	210 (22.29)	4 (9.76)		29 (17.68)	4 (9.76)
Low	291 (30.89)	9 (21.95)		30 (18.29)	9 (21.95)
Intermediate	147 (15.61)	8 (19.51)		22 (13.41)	8 (19.51)
High	294 (31.21)	20 (48.78)		83 (50.61)	20 (48.78)
Operate time (min)			0.336			0.627
mean ± SD	139 ± 78	151 ± 63		145 ± 67	151 ± 63
Median (IQR)	120 (80-180)	150 (120-180)		140 (90-190)	150 (120-180)
Intraoperative tumor rupture			0.376			0.490
Yes	10 (1.06)	1 (2.44)		2 (1.22)	1 (2.44)
No	932 (98.94)	40 (97.56)		162 (98.78)	40 (97.56)
Hospitalization time in d			0.226			0.442
mean ± SD	13.55 ± 6.32	14.78 ± 7.66		13.96 ± 5.69	14.78 ± 7.66
Median (IQR)	12 (10-15)	14 (9-16)		13 (11-16)	14 (9-16)
Postoperative complications			0.391			0.610
Present	179 (19.00)	10 (24.39)		34 (20.73)	10 (24.39)
Absent	763 (81.00)	31 (73.61)		130 (79.27)	31 (73.61)
Imatinib treatment			0.187			0.832
Yes	298 (31.63)	17 (41.46)		71 (43.29)	17 (41.46)
No	644 (68.37)	24 (58.54)		93 (56.71)	24 (58.54)

Bold values indicate P < 0.05. HPF: High power field; IQR: Interquartile range; MGIST: Multiple gastrointestinal stromal tumors; NIH: National Institutes of Health; SD: SD; SGIST: Solitary gastrointestinal stromal tumors.