Impact of radiogenomics in esophageal cancer on clinical outcomes: A pilot study

Table 2 Selected radiomic features after the three feature selection steps for binary outcomes

Selected radiomic features, stage	Stage I-II, mean ± SD	Stage III-IV, mean ± SD	P value
Wavelet-HLH first order entropy	0.62 ± 0.13	0.21 ± 0.31	0.031
Wavelet-LHL GLDM high gray level emphasis	0.59 ± 0.32	0.21 ± 0.21	0.044
Wavelet-HLL GLDM high gray level run emphasis	0.67 ± 0.37	0.2 ± 0.18	0.019
Wavelet-HLL GLDM gray level variance	0.74 ± 0.29	0.22 ± 0.29	0.007
Wavelet-HLL GLDM cluster prominence	0.59 ± 0.36	0.14 ± 0.3	0.019
Wavelet-HLL GLDM inverse variance	0.27 ± 0.3	0.68 ± 0.23	0.028
Wavelet-HLL GLDM maximum probability	0.14 ± 0.17	0.58 ± 0.32	0.042
Wavelet-HLL GLDM dependence entropy	0.78 ± 0.18	0.42 ± 0.25	0.028
Wavelet-HLL GLDM dependence variance	0.2 ± 0.21	0.48 ± 0.26	0.044
Wavelet-HLL GLSZM size zone non uniformity	0.69 ± 0.39	0.15 ± 0.15	0.028
Wavelet-HLL GLSZM small area low gray level emphasis	0.02 ± 0.03	0.24 ± 0.33	0.041
Wavelet-HLL first order 90 percentile	0.55 ± 0.39	0.17 ± 0.16	0.029
Wavelet-HHH GLRLM gray level non uniformity normalized	0.39 ± 0.27	0.87 ± 0.19	0.007
Wavelet-HHH GLCM joint entropy	0.68 ± 0.22	0.2 ± 0.27	0.021
Wavelet-HHH GLCM Contrast	0.78 ± 0.19	0.45 ± 0.25	0.021
Wavelet-HHH GLSZM gray level variance	0.91 ± 0.11	0.3 ± 0.39	0.021
Wavelet-HHH GLSZM zone percentage	0.83 ± 0.13	0.35 ± 0.34	0.029
Wavelet-HHH first order 10 percentile	0.11 ± 0.08	0.46 ± 0.35	0.029
Wavelet-HHL NGTDM strength	0.66 ± 0.3	0.28 ± 0.3	0.044
Wavelet-HHL GLCM cluster shade	0.51 ± 0.49	0.04 ± 0.03	0.007
Wavelet-HHL first order Entropy	0.68 ± 0.33	0.27 ± 0.21	0.029
Wavelet-HHL first order mean absolute deviation	0.66 ± 0.35	0.25 ± 0.18	0.029
Wavelet-LLH NGTDM complexity	0.23 ± 0.13	0.13 ± 0.29	0.044
Wavelet-LLH GLDM high gray level emphasis	0.34 ± 0.23	0.14 ± 0.29	0.044
Wavelet-LLL GLDM small dependence high gray level emphasis	0.67 ± 0.32	0.25 ± 0.22	0.029
Selected radiomic features (alcohol history)	No alcohol history (mean ± SD)	Alcohol history (mean ± SD)	P value
Original first order kurtosis	0.37 ± 0.32	0.12 ± 0.12	0.037
Wavelet-LHH first order interquartile range	0.24 ± 0.24	0.5 ± 0.25	0.049
Wavelet-LHH first order mean	0.94 ± 0.04	0.75 ± 0.31	0.013
Wavelet-HHL first order median	0.62 ± 0.2	0.37 ± 0.19	0.026
Wavelet-LLH first order uniformity	0.68 ± 0.27	0.41 ± 0.26	0.037

The first column includes the two binary clinical outcomes investigated in this study (stage, alcohol history). GLCM: Gray level co-occurrence matrix; GLDM: Gray level dependence matrix; GLRLM: Gray level run length matrix; GLSZM: Gray level size zone matrix; H: High-pass filter; L: Low-pass filter; NGTDM: Neighboring gray tone difference matrix; SD: Standard deviation.