Treatment of hepatitis B virus infection in children and adolescents

Table 2 Antiviral drugs approved for children and adolescents with chronic hepatitis B virus infection[14]

	Ages approved for drug administration	Drug dosage	Drug formulations
Interferon alfa-2b	≥ 1 yr	6 million UI/m2 three times a week	Subcutaneous injection
Peginterferon alfa-2a	≥ 3 yr	180 µg/1.73 m2 once a week	Subcutaneous injection
Lamivudine	≥ 3 yr	3 mg/kg daily (maximum 100 mg)	Oral solution (5 mg/mL) or tablets (100 mg)
Entecavir	≥ 2 yr	10-30 kg: 0.015 mg/kg daily (maximum 0.5 mg)	Oral solution (0.05 mg/mL) or tablets (0.5 mg and 1 mg)
		> 30 kg: 0.5 mg daily
Adefovir	≥ 12 yr	10 mg daily	Tablets (10 mg)
Tenofovir disoproxil fumarate	≥ 2 yr1	8 mg/kg daily (maximum 300 mg)	Oral powder (40 mg per 1 g) or tablets (150 mg, 200 mg, 250 mg and 300 mg)
	≥ 12 yr1	300 mg daily
Tenofovir alafenamide	≥ 12 yr2	25 mg daily	Tablet (25 mg)

¹Approved for ≥ 2 yr by the European Medicines Agency and ≥ 12 yr by the United States Food and Drug Administration.

²Approved independent of age for weight > 35 kg.