Histone methylation in pancreatic cancer and its clinical implications

Table 2 Histone demethylase that plays a major role in pancreatic cancer

Family	Subfamily		Alias	Site	Function in pancreatic cancer
KDM1	KDM1A		LSD1	H3K4me1	Promote the occurrence of cancer[83]
	KDM1B		LSD2, AOF1	H3K4me2	Related to tumor tissue apoptosis[84]
Jumonji C	KDM2B		Ndy1, FBXL10, JHDM1B	H3K4me3, H3K36me2	Promote senescence of primary cells[109,110]
	KDM3A		JMJD1A, JHDM2A	H3K9me2 (preferential), H3K9me1	Regulate biological and pathological processes, including embryonic development, stem cell self-renewal and differentiation, genome integrity and tumorigenesis[191,192]
	KDM4 family	KDM4A	JMJD2A	H3K36me3, H3K9me3	Destruction of homologous recombination[120,138]
		KDM4B	JMJD2B	H3K9me3	Promote epithelial-mesenchymal transition[123]
		KDM4D	JMJD2D	H3K9me2/me3	Stimulates in vitro proliferation and cell survival, and plays a vital role in DNA double-strand break repair[193,194]
	KDM5A		JARID1A, RBBP2	H3K4me2	Promote the inhibition of active transcription and repair of DNA double-strand breaks[139,195]
	KDM6 family	KDM6A	UTX	H3K27me2/me3	The effect of KDM6A on PC tissue is currently unclear[196]
		KDM6B	JMJD3	H3K27me2/me3	Enhance the aggressiveness of cancer cells[176]
	PHD finger and zinc finger protein family	KDM7A	JHDM1D	H3K9me2, H3K27me2	May be related to the upregulation of E-cadherin gene expression[93]

All current research on reprogramming histone demethylases that play a role in pancreatic cancer. The table is sorted by family. PC: Pancreatic cancer; PHD: Plant homeodomain.