Pancreatic cancer in 2021: What you need to know to win

Table 1 Genetic syndromes predisposing to pancreatic cancer (the frequency of mutated genes among patients with pancreatic ductal adenocarcinoma is indicated in brackets)

Genetic syndrome	Mutated genes
Hereditary breast/ovarian cancer syndrome[36,37]	BRCA1 (0.7%), BRCA2 (1.4%), PALB2 (1%)
Familial atypical multiple mole melanoma syndrome[38]	CDKN2A (0.7%)
Peutz-Jeghers syndrome[39]	STK11
Familial adenomatous polyposis	APC (0.4%)
Lynch syndrome[40]	MLH1, MSH2 (0.4%), PMS2 (0.3%)
Hereditary pancreatitis[41]	PRSS1, SPINK1
Ataxia telangectasia[42]	ATM (1.4%)
Li-Fraumeni syndrome[42]	P53 (0.4%)