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©The Author(s) 2021.
World J Gastroenterol. Sep 14, 2021; 27(34): 5737-5752
Published online Sep 14, 2021. doi: 10.3748/wjg.v27.i34.5737
Published online Sep 14, 2021. doi: 10.3748/wjg.v27.i34.5737
Table 3 Clinical characteristics of colorectal cancer patients and MTNR1B genotypes (rs10830963 and rs1447352)
| Variables | Total | rs10830963 (C>G) | rs1447352 (A>G) | ||||||||||
| CC (%) | CG (%) | GG (%) | P value | CC + CG (%) | P value | GG (%) | GA (%) | AA (%) | P value | GG + GA (%) | P value | ||
| Sex | |||||||||||||
| Male | 39 (41.5) | 7 (33.3) | 22 (44.9) | 10 (43.5) | 0.66 | 29 (41.4) | 1.00 | 4 (66.7) | 16 (43.2) | 19 (38.0) | 0.40 | 20 (46.5) | 0.53 |
| Female | 55 (58.5) | 14 (66.7) | 27 (55.1) | 13 (56.5) | 41 (58.6) | 2 (33.3) | 21 (56.8) | 31 (62.0) | 23 (53.5) | ||||
| Age at surgery | |||||||||||||
| mean ± SD (yr) | 64.2 ± 13.8 | 67.0 ± 14.0 | 61.4 ± 13.9 | 66.8 ± 13.1 | 0.16 | 63.1 ± 14.0 | 0.26 | 69.7 ± 14.1 | 64.4 ± 14.0 | 63.0 ± 13.8 | 0.53 | 65.1 ± 14.0 | 0.47 |
| < 65 | 50 (53.2) | 11 (52.4) | 28 (57.1) | 11 (47.8) | 0.75 | 39 (55.7) | 0.63 | 3 (50.0) | 18 (48.6) | 29 (58.0) | 0.68 | 21 (48.8) | 0.41 |
| ≥ 65 | 44 (46.8) | 10 (47.6) | 21 (42.9) | 12 (52.2) | 31 (44.3) | 3 (50.0) | 19 (51.4) | 21 (42.0) | 22 (51.2) | ||||
| Stage | |||||||||||||
| I | 12 (12.8) | 2 (9.5) | 6 (12.2) | 4 (17.4) | 0.56 | 8 (11.4) | 0.30 | 0 (0) | 4 (10.8) | 8 (16.0) | 0.54 | 4 (9.3) | 0.60 |
| II | 34 (36.2) | 8 (38.1) | 18 (36.7) | 7 (30.4) | 26 (37.1) | 1 (16.7) | 15 (40.5) | 17 (34.0) | 16 (37.2) | ||||
| III | 30 (31.9) | 9 (42.9) | 16 (32.7) | 5 (21.7) | 25 (35.7) | 4 (66.7) | 12 (32.4) | 14 (28.0) | 16 (37.2) | ||||
| IV | 18 (19.1) | 2 (9.5) | 9 (18.4) | 7 (30.4) | 11 (15.7) | 1 (16.7) | 6 (16.2) | 11 (22.0) | 7 (16.3) | ||||
| Adjuvant chemotherapya | |||||||||||||
| No | 23 (24.5) | 5 (23.8) | 12 (25.5) | 6 (30.0) | 0.90 | 17 (25.0) | 0.77 | 1 (16.7) | 8 (22.2) | 14 (30.4) | 0.61 | 9 (21.4) | 0.47 |
| Yes | 65 (69.1) | 16 (76.2) | 35 (74.5) | 14 (70.0) | 51 (75.0) | 5 (83.3) | 28 (77.8) | 32 (69.6) | 33 (78.6) | ||||
| Tumor locationa | |||||||||||||
| Colon | 74 (78.7) | 20 (95.2) | 41 (87.2) | 13 (65.0) | 0.02 | 61 (89.7) | 0.01 | 6 (100) | 34 (94.4) | 34 (73.9) | 0.02 | 40 (95.2) | < 0.001 |
| Rectum | 14 (14.9) | 1 (4.85) | 6 (12.8) | 7 (35.0) | 7 (10.3) | 0 (0) | 2 (5.6) | 12 (26.1) | 2 (4.8) | ||||
| CDKN2A gene | |||||||||||||
| Unmethylation | 43 (45.7) | 12 (57.1) | 17 (34.7) | 13 (56.5) | 0.10 | 29 (41.4) | 0.31 | 4 (66.7) | 16 (43.2) | 22 (44.0) | 0.55 | 20 (46.5) | 0.97 |
| Methylation | 51 (54.3) | 9 (42.9) | 32 (65.3) | 10 (43.5) | 41 (58.6) | 2 (33.3) | 21 (56.8) | 28 (56.0) | 23 (53.5) | ||||
| MLH1 gene | |||||||||||||
| Unmethylation | 77 (81.9) | 18 (85.7) | 39 (79.6) | 19 (82.6) | 0.83 | 57 (81.4) | 1.00 | 5 (83.3) | 31 (83.8) | 40 (80.0) | 0.90 | 36 (83.7) | 0.79 |
| Methylation | 17 (18.1) | 3 (14.3) | 10 (20.4) | 4 (17.4) | 13 (18.6) | 1 (16.7) | 6 (16.2) | 10 (20.0) | 7 (16.3) | ||||
| MGMT gene | |||||||||||||
| Unmethylation | 46 (48.9) | 8 (38.1) | 26 (53.1) | 12 (52.2) | 0.50 | 34 (48.6) | 0.95 | 4 (66.7) | 18 (48.6) | 24 (48.0) | 0.68 | 22 (51.2) | 0.92 |
| Methylation | 48 (51.1) | 13 (61.9) | 23 (46.9) | 11 (47.8) | 36 (51.4) | 2 (33.3) | 19 (51.4) | 26 (52.0) | 21 (48.8) | ||||
| Death in 5 yr | |||||||||||||
| No | 76 (80.9) | 19 (90.5) | 43 (87.8) | 13 (56.5) | < 0.001 | 62 (88.6) | < 0.001 | 6 (100) | 33 (89.2) | 36 (72.0) | 0.06 | 39 (90.7) | 0.03 |
| Yes | 18 (19.1) | 2 (9.5) | 6 (12.2) | 10 (43.5) | 8 (11.4) | 0 (0) | 4 (10.8) | 14 (28.0) | 4 (9.3) | ||||
- Citation: Lee CC, Kuo YC, Hu JM, Chang PK, Sun CA, Yang T, Li CW, Chen CY, Lin FH, Hsu CH, Chou YC. MTNR1B polymorphisms with CDKN2A and MGMT methylation status are associated with poor prognosis of colorectal cancer in Taiwan. World J Gastroenterol 2021; 27(34): 5737-5752
- URL: https://www.wjgnet.com/1007-9327/full/v27/i34/5737.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i34.5737