Radiomics for predicting perineural invasion status in rectal cancer

Table 3 Comparisons of variables and models in the training and validation cohorts

	The training set				The validation set
	AUC	SEN (%)	SPE (%)	P value	AUC	SEN (%)	SPE (%)	P value
CEA	0.597 (0.533-0.660)	50.00	76.38	< 0.001	0.635 (0.502-0.754)	96.55	40.63	0.042
cT stage	0.613 (0.549-0.675)	84.35	33.86	< 0.001	0.589 (0.456-0.714)	75.86	43.75	0.004
cN stage	0.670 (0.607-0.729)	42.61	84.25	< 0.001	0.684 (0.553-0.797)	86.21	40.63	0.045
Rad-score	0.760 (0.701-0.812)	72.17	69.29	0.020	0.782 (0.658-0.878)	68.97	78.12	0.640
Clinical model	0.718 (0.657-0.774)	63.48	70.08	< 0.001	0.674 (0.542-0.789)	65.52	71.87	0.045
Combined model	0.828 (0.774-0.873)	66.09	88.19		0.801 (0.679-0.892)	62.07	93.75

P value: Compared with the combined model by DeLong’s test. AUC: Area under the receiver operating characteristic curve; SEN: Sensitivity; SPE: Specificity; CEA: Carcinoembryonic antigen.