Neutrophil extracellular traps in gastrointestinal cancer

Table 1 Role of neutrophil extracellular traps in gastric cancer

Ref.	Cell lines	Model (in vitro, in vivo, human)	Conclusion
Yang et al[64], 2015	-	Human	NETs contribute to the hypercoagulable state in GC patients with stage III/IV
Kanamaru et al[68], 2018	MKN45, NUGC-4, OCUM-1	In vitro, in vivo	NETs on peritoneal surface assist the clustering and growth of GC tumor cells disseminated in abdomen
Tao et al[74], 2018	BGC-823	In vitro, in vivo	NET formation is inhibited by Sal B and DHT I at the earlier stage
Kumagai et al[72], 2020	MKN45, NUGC-4, OCUM-1	In vitro, human	NETs formation is enhanced under surgical stress and can effectively trap circulating tumor cells
Li et al[78], 2020	BGC-823, SGC7901, MKN28	In vitro, human	NETs destruction promotes the apoptosis and inhibits the invasion of gastric cancer cells by regulating the expression of Bcl-2, Bax and NF-κB
Zhang et al[94], 2020	-	Human	NETs have novel diagnostic, therapeutic predictive, and prognostic value in GC patients

NETs: Neutrophil extracellular traps; GC: Gastric cancer.