Prediction of the severity of colorectal lesion by fecal hemoglobin concentration observed during previous test in the French screening program

Table 5 Analysis of the relationship between the diagnosis and severity of colorectal lesions and the predictive factors

Predictive factors	Risk analysis of colorectal lesions in a logistic regression model				Risk analysis of the severity of colorectal lesions in an ordered polytomous regression model
	Univariate		Multivariate		Univariate		Multivariate
	Unadjusted OR (95%CI)	P value1	Adjusted OR (95%CI)	P value1	Unadjusted OR (95%CI)	P value2	Adjusted OR (95%CI)	P value2
Fhb-1 (ngHb/mL) (Ref.: 0)
0-50	1.1 (0.8; 1.6)	0.6	1.1 (0.8; 1.6)	0.5	1.4 (1.0; 2.0)	0.1	1.3 (0.9; 1.8)	0.1
50-100	2.5 (2.1; 3.1)	< 10-3	2.4 (2.0; 3.0)	< 10-3	1.8 (1.6; 2.1)	< 10-3	1.8 (1.6; 2.0)	< 10-3
100-150	3.0 (2.3; 3.9)	< 10-3	2.9 (2.2; 3.8)	< 10-3	2.6 (2.2; 3.1)	< 10-3	2.6 (2.2; 3.0)	< 10-3
gFOBT campaign participation (Ref.: Yes-gFOBT)
New entrant	0.9 (0.7; 1.0)	0.04	3.3 (2.2; 5.0)	< 10-3	0.6 (0.6; 0.8)	< 10-3	0.1 (0.1; 0.2)	< 10-3
No-gFOBT	1.1 (1.0; 1.2)	0.2	2.8 (1.9; 4.1)	< 10-3	0.8 (0.7; 0.9)	< 10-3	0.2 (0.1; 0.3)	< 10-3
Age (yr) at test(-1) (Ref.: 50-54)
55-59	1.1 (1.0; 1.3)	0.2	1.3 (1.0; 1.6)	0.04	1.1 (0.9; 1.3)	0.4	0.8 (0.6; 1.0)	0.02
60-64	1.3 (1.1; 1.5)	< 10-3	1.4 (1.2; 1.8)	0.001	1.0 (0.9; 1.2)	0.5	0.7 (0.6; 0.9)	0.004
65-69	1.3 (1.1; 1.5)	< 10-3	1.4 (1.1; 1.8)	0.002	1.3 (1.1; 1.5)	0.002	0.9 (0.7; 1.1)	0.2
≥ 70	1.5 (1.3; 1.8)	< 10-3	1.7 (1.3; 2.1)	< 10-3	1.2 (1.0; 1.4)	0.01	0.8 (0.6; 1.0)	0.07
Gender (Ref.: Female)
Male	1.7 (1.5; 1.9)	< 10-3	1.7 (1.5; 1.8)	< 10-3	1.2 (1.1; 1.3)	0.002	1.2 (1.1; 1.3)	< 10-3
Delay (mo) between test(-1) and test0 (Ref.: < 24)
24-30	1.3 (1.1; 1.4)	< 10-3	1.3 (1.1; 1.5)	< 10-3	1.0 (0.9; 1.1)	0.9	1.0 (0.9; 1.1)	0.9
> 30	1.9 (1.7; 2.2)	< 10-3	2.1 (1.7; 2.6)	< 10-3	0.6 (0.5; 0.7)	< 10-3	0.6 (0.5; 0.7)	< 10-3
Number of tests completed before test(-1) (Ref.: 0)
1	1.1 (0.9; 1.2)	0.3	2.7 (1.9; 3.9)	< 10-3	1.2 (1.0; 1.4)	0.03	0.3 (0.2; 0.4)	< 10-3
2	1.0 (0.9; 1.2)	0.7	2.7 (1.8; 4.1)	< 10-3	1.2 (1.0; 1.3)	0.03	0.2 (0.1; 0.3)	< 10-3
3	1.1 (1.0; 1.3)	0.1	2.9 (1.9; 4.4)	< 10-3	1.4 (1.2; 1.6)	< 10-3	0.3 (0.2; 0.4)	< 10-3
4	1.3 (1.1; 1.5)	< 10-3	3.5 (2.3; 5.2)	< 10-3	1.1 (1.0; 1.3)	0.1	0.2 (0.1; 0.3)	< 10-3

¹P values were estimated from likelihood ratio tests based on data from 11254 people who completed a colonoscopy.

²P values were estimated from likelihood ratio tests based on data from 8748 people diagnosed with colorectal lesion after colonoscopy. Fhb_(-1): Fecal hemoglobin measured at test_(-1) (penultimate test); gFOBT: Guaiac fecal occult blood test; OR: Odds ratio; CI: Confidence interval.