Prediction of the severity of colorectal lesion by fecal hemoglobin concentration observed during previous test in the French screening program

Table 2 Colonoscopy detection rate, number and severity of colorectal lesions according to the previous rate and the last rate of fecal hemoglobin

Fhb(0) by Fhb(-1)			Colonoscopy detection rate		Number of colorectal lesions by Severity
Fhb(-1) (ngHb/mL)	Fhb(0) (ngHb/mL)	Number (% in subtotal)	Number Colo (%Positive Colo)	P value1	Nb. of colorectal lesions	Polyps			CRC
						LRP	HRP	UP	S-0	S-I	S-II	S-III	S-IV	USC
0				0.8
	0	257589 (92.0)
	0-50	1805 (0.6)
	50-100	8275 (3.0)
	100-149	2688 (1.0)
	150-300	4903 (1.7)	4778 (75.5)		3609	980	918	1601	35	38	5	6	2	24
	≥ 300	4752 (1.7)	4590 (75.7)		3476	910	851	1469	50	61	26	41	13	55
	Subtotal	280012 (100.0)	9368 (75.6)		7085	1890	1769	3070	85	99	31	47	15	79
0–50				0.3
	0	1328 (79.1)
	0-50	30 (1.8)
	50-100	112 (6.7)
	100-149	36 (2.1)
	150-300	86 (5.1)	85 (74.1)		63	17	18	24	1	2	1	0	0	0
	≥ 300	88 (5.2)	87 (80.5)		70	10	23	32	2	2	0	0	0	1
	Subtotal	1680 (100.0)	172 (77.3)		133	27	41	56	3	4	1	0	0	1
50–100				0.7
	0	6589 (75.1)
	0-50	106 (1.2)
	50-100	700 (7.9)
	100-149	237 (2.7)
	150-300	540 (6.2)	525 (88.4)		464	97	174	175	7	4	2	2	0	3
	≥ 300	604 (6.9)	583 (89.0)		519	80	186	195	18	12	10	7	2	9
	Subtotal	8776 (100.0)	1108 (88.7)		983	177	360	370	25	16	12	9	2	12
100–149				0.3
	0	2244 (68.4)
	0-50	49 (1.5)
	50-100	259 (7.9)
	100-149	109 (3.3)
	150-300	293 (8.9)	286 (88.8)		254	52	103	87	4	2	3	1	0	2
	≥ 300	328 (10.0)	320 (91.6)		293	36	127	81	16	9	6	7	4	7
	Subtotal	3282 (100.0)	606 (90.3)		547	88	230	168	20	11	9	8	4	9

¹Pearson Chi-2 test or Fisher's exact test. Fhb₍₀₎: Fecal hemoglobin measured at test₍₀₎ (last screening test); Fhb_(-1): Fecal hemoglobin measured at test_(-1) (penultimate test); CRC: Colorectal cancer; Colo: Colonoscopy; HRP: High risk polyps; LRP: Low risk polyps; UP: Unspecified-polyp; USC: Unspecified stage of colorectal cancer; S-0: Colorectal cancer Stage-0 (pTisN₀M₀), S-I: Stage-I (pT_1-2N₀M₀); S-II: Stage-II (pT₃N₀M₀ or pT₄N₀M₀); S-III: Stage-III (pT₁-T₂N₁M₀ or pT₁N₂M₀ or pT₃-T₄N₁M₀ or pT₂-T₃N₂M₀ or pT₄N₂M₀); S-IV: Stage-IV (any T, any N, M₁).