Prediction of the severity of colorectal lesion by fecal hemoglobin concentration observed during previous test in the French screening program

Table 1 Result of the last test completed, based on the characteristics of the study population

Characteristics	Result of the last test [test(0)]
	Positive test and colonoscopy completion rate			Colonoscopy detection rate		Number of the colorectal lesions
	Nb. (%T+)	P value1	Number T+ (% Colo in T+)	Number Colo (% Positive Colo)	P value1	All lesions	Polyps				CRC
							LRP	HRP		UP	S-0	S-I	S-II	S-III	S-IV	USC
Overall	293750 (4.0)		11594 (97.1)	11254 (77.7)		8748	2182	2400		3664	133	130	53	64	21	101
Fhb(-1) (ngHb/mL)		< 10-3			< 10-3
0	280012 (3.5)		9655 (97.0)	9368 (75.6)		7085	1890	1769		3070	85	99	31	47	15	79
0-50	1680 (10.4)		174 (98.9)	172 (77.3)		133	27	41		56	3	4	1	0	0	1
50–100	8776 (13.0)		1144 (96.9)	1108 (88.7)		983	177	360		370	25	16	12	9	2	12
100-150	3282 (18.9)		621 (97.6)	606 (90.3)		547	88	230		168	20	11	9	8	4	9
gFOBT campaign participation		< 10-3			0.03
Yes-gFOBT	213476 (4.2)		8874 (97.0)	8605 (77.8)		6695	1760	1906		2603	112	109	44	59	17	85
New entrant	40199 (2.9)		1156 (97.5)	1127 (75.1)		846	168	203		456	8	6	0	0	1	4
No-gFOBT	40075 (3.9)		1564 (97.3)	1522 (79.3)		1207	254	291		605	13	15	9	5	3	12
Age (yr) at test(-1)		< 10-3			< 10-3
50-54	57625 (3.0)		1727 (97.9)	1690 (73.7)		1245	276	348		582	10	14	1	6	1	7
55-59	62489 (3.5)		2166 (97.3)	2107 (75.6)		1592	389	445		687	21	19	4	7	3	17
60-64	64141 (3.9)		2514 (97.4)	2449 (78.4)		1920	509		503	807	28	19	17	15	7	15
65-69	63915 (4.7)		2997 (97.0)	2907 (78.7)		2287	592		647	886	38	54	14	17	5	34
≥ 70	45580 (4.8)		2190 (95.9)	2101 (81.1)		1704	416		457	702	36	24	17	19	5	28
Gender		< 10-3			< 10-3
Female	160181 (3.3)		5343 (97.1)	5188 (72.8)		3778	962		937	1663	59	51	15	33	11	47
Male	133569 (4.7)		6251 (97.0)	6066 (81.9)		4970	1220		1,463	2001	74	79	38	31	10	54
Delay (mo) between test(-1) and test(0)		< 10-3			< 10-3
≤ 24	40422 (5.2)		2111 (94.3)	1991 (72.2)		1437	435		435	482	21	23	12	12	0	17
24-30	163470 (4.0)		6538 (97.7)	6390 (76.9)		4916	1322		1440	1833	99	83	29	39	14	57
> 30	89858 (3.3)		2945 (97.6)	2873 (83.4)		2395	425		525	1349	13	24	12	13	7	27
Nb. of tests completed before test(-1)		< 10-3			0.01
0	68839 (3.5)		2421 (97.1)	2351 (76.1)		1790	396		465	855	19	21	9	5	4	16
1	54790 (3.7)		2044 (97.7)	1996 (77.6)		1548	364		432	667	20	26	6	13	6	14
2	55794 (4.0)		2245 (97.1)	2180 (76.6)		1670	434		472	678	25	17	11	12	2	19
3	56716 (4.4)		2514 (97.3)	2445 (77.9)		1905	553		562	649	34	37	13	24	5	28
4	57611 (4.1)		2370 (96.3)	2282 (80.4)		1835	435		469	815	35	29	14	10	4	24

¹Pearson Chi-2 test or Fisher's exact test. Fhb₍₀₎: Fecal hemoglobin measured at test₍₀₎ (last screening test); Fhb_(-1): Fecal hemoglobin measured at test_(-1) (penultimate test); CRC: Colorectal cancer; Colo: Colonoscopy; gFOBT: Guaiac fecal occult blood test; HRP: High risk polyps; LRP: Low risk polyps; UP: Unspecified-polyp; USC: Unspecified stage of colorectal cancer; S-0: Colorectal cancer Stage-0 (pTisN₀M₀), S-I: Stage-I (pT_1-2N₀M₀); S-II: Stage-II (pT₃N₀M₀ or pT₄N₀M₀); S-III: Stage-III (pT₁-T₂N₁M₀ or pT₁N₂M₀ or pT₃-T₄N₁M₀ or pT₂-T₃N₂M₀ or pT₄N₂M₀); S-IV: Stage-IV (any T, any N, M₁); T+: Positive test.