Histological differentiation impacts the tumor immune microenvironment in gastric carcinoma: Relation to the immune cycle

Table 3 Relationship between immunophenotype and histological pattern of gastric carcinoma

Characteristics	ID TIME	IE TIME	Inf TIME	Total number
Histological types of GC, n (%)
Intestinal	1 (3.2)	5 (16.1)	25 (80.7)	31 (62)
Diffuse	8 (53.3)	5 (33.3)	2 (13.3)	15 (30)
Mucinous	1 (25)	3 (75)	0	4 (8)
				P < 0.001
PD-L1 expression status, n (%)
PD-L1 positive GCs	1 (5.6)	0	8 (94.4)	9 (18)
PD-L1 negative GCs	9 (21.9)	13 (31.8)	19 (46.3)	41 (82)
Total number	10	13	27	50
				P < 0.001

TIME: Tumor immune microenvironment; PD-L1: Programmed death-ligand 1; GC: Gastric carcinoma; ID: Immune desert; IE: Immune-excluded.