Screening and prevention of hepatitis C virus reactivation during chemotherapy

Table 1 Recommended definitions of quiescent hepatitis C virus infection, hepatitis C virus reactivation and hepatitis C virus-related hepatitis flare in cancer patients receiving chemotherapy

Term	Definition	Ref.
Quiescent HCV infection	An HCV infection with a positive serum HCV-RNA and normal serum levels of liver enzymes	IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 59[30]
HCV reactivation	Increase in HCV-RNA level during chemotherapy of ≥ 1 log10 IU/mL over baseline	Talima et al[17]
HCV-related hepatitis flare	Unexplained increase in ALT to 3 times the upper limit of normal during chemotherapy and increase in HCV-RNA level of ≥ 1 log10 IU/mL over baseline	Torres et al[18]

IARC: International Agency for Research on Cancer; HCV: Hepatitis C virus.