Helicobacter pylori eradication: Exploring its impacts on the gastric mucosa

Table 3 Studies on gastric microbiota alteration after eradication

Ref.	Year	Total subjects	Follow-up time	Age	Regimen	Study group		Main outcomes
				1 = Adults	1 = TT for 7-14 d	HEG	H. pylori (-)
				2 = Children	2 = QT for 10-14 d
Li et al[93]	2017	33	Day 0 and week 9	1	1	17	16	Bacterial diversity increased and the relative abundance of Helicobacter decreased, while the relative abundance of other phyla increased
Serrano et al[99]	2019	16	Day 0 and month 2	2	1	11	5	Bacterial diversity increased and the structures of the uninfected group were restored
Guo et al[98]	2020	164	Day 0 and month 6	1	2	115	49	Bacterial diversity returned to the level of the control group. The structure of the bacteria was different after treatment compared to the control group. Microbiota functional capacities were changed
He et al[86]	2019	17	Weeks 0, 6, and 26	1	2	10	NA	Bacterial diversity increased and structure and microbiota functional capacities were changed
Miao et al[82]	2020	55	Day 0 and week 4	2	1, 2 and STP	11	8	Diversity was similar compared to the control group. The bacterial structure became close to controls
Sung et al[35]	2020	102	Day 0 and 1 year	1	1	102	NA	Bacterial diversity increased and structure was changed

HEG: Helicobacter pylori eradication group; H. pylori: Helicobacter pylori; NA: Not applicable; QT: Quadruple therapy; TT: Triple therapy; STP: Sequential therapy with proton pump inhibitor and amoxicillin.