Estrogen augmented visceral pain and colonic neuron modulation in a double-hit model of prenatal and adult stress

Figure 4 Effects of Letrozole treatment on colon dorsal root ganglion neuron excitability. A: Rheobase (n = 45 cells in 6 rats in each group, t-test, ^cP < 0.001 vs Veh. + chronic adult stress [CAS] + chronic prenatal stress [CPS]); B: Membrane input resistance (RIn) (t-test, ^aP < 0.05); C: Action potential (AP) overshoot (t-test, ^aP < 0.05); D: Number of APs elicited by current injection at 2 × and 3 × rheobase (two-way ANOVA, ^aP < 0.05; ^bP < 0.01).