Estrogen augmented visceral pain and colonic neuron modulation in a double-hit model of prenatal and adult stress

Table 2 Electrophysiological characteristics of colon related DRG neuron after Letrozole treatment

Classification	Veh. + CAS + CPS, n = 60	Let + CAS + CPS, n = 27
Spontaneous spike number	34.6 ± 11.3	8.04 ± 4.62c
Membrane capacitance (pF)	86.8 ± 7.1	83.7 ± 6.7
Action potential threshold (mV)	-34.6 ± 1.6	-27.6 ± 2.1a
Resting membrane potential (mV)	-54.9 ± 1.3	-54.6 ± 2.2
Cell diameter (μm)	31 ± 0.5	27 ± 1.6
Time constant (um)	502.7 ± 34.5	454.0 ± 36.6
Action potential amplitude (mV)	90.9 ± 3.7	89.8 ± 7.2
Duration (ms)	8.67 ± 0.63	10.70 ± 2.22

Values are means ± standard error.

^aP < 0.05;

^cP < 0.001 vs control group. CAS: Chronic adult stress; CPS: Chronic prenatal stress.