Gut microbiome in acute pancreatitis: A review based on current literature

doi:10.3748/wjg.v27.i30.5019

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Aug 14, 2021 (publication date) through Jul 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 14, 2021; 27(30): 5019-5036
Published online Aug 14, 2021. doi: 10.3748/wjg.v27.i30.5019

Table 6 Altered microbiome composition observed in acute pancreatitis of increasing severity

No.	Techniques used for microbiome profiling	MAP	MSAP	SAP	Ref.
1	qPCR (Fecal samples), performed only on MAP and SAP patients	Enterococcus↑	NA	Enterococcus↑	[79]
		Enterobacteriaceae↑	NA	Enterobacteriaceae↑
		Bifidobacterium↓		Bifidobacterium↓
2	16S rRNA gene sequencing (Fecal samples)	Finegoldia↑	NA	Acinetobacter↑	[83]
				Stentrophomonas↑
				Geobacillus↑
				Bacteroides↓
				Alloprevotella↓
				Blautia↓
				Gemella↓
3	16S rRNA sequencing (Fecal sample)	Enterobacteriaceae↑	NA	Enterobacteriaceae↑	[85]
		Enterococcus↑		Enterococcus↑
		Bifidobacterium↓		Bifidobacterium↓
		Bifidobacterium↓		Blautia↓
4	16S rRNA gene sequencing (Rectal swab)	Bacteroides↑	Bacteroides↑	Bacteroides↑	[82]
		Escherichia/Shigella↑	Escherichia/Shigella↑	Escherichia/Shigella↑
		Enterococcus↑	Enterococcus↑	Enterococcus↑
		Enterococcus↑	Enterococcus↑	Eubacterium hallii↓
		Finegoldia↑	Anaerococcus↑	Acinetobacter↓
		Finegoldia↑	Anaerococcus↑	Stenotrophomonas↓
		Blautia↓	Eubacterium hallii↓	Bacteroides↓
		Blautia↓	Eubacterium hallii↓	Blautia↓
5	Shotgun metagenomics (Fecal sample)	Thermoprotei↑	Sulfolobus↑	Sulfolobus↑	[86]
		Crenarchaeota↑	Methanobrevibacter ruminantium↑	Methanomicrobiales - archaeon 53_19↑
		Streptococcus↑	Methanosarcina - Thermophila↑	Enterococcus↑
		Anaerostipes hadrus↓	Anaerostipes hadrus↓	Blautia↓
			Escherichia coli↑

MAP: Mild acute pancreatitis; MSAP: Moderately severe acute pancreatitis; NA: Not available; SAP: Severe acute pancreatitis; ↑: Higher level; ↓: Lower level.

Citation: Patel BK, Patel KH, Bhatia M, Iyer SG, Madhavan K, Moochhala SM. Gut microbiome in acute pancreatitis: A review based on current literature. World J Gastroenterol 2021; 27(30): 5019-5036
URL: https://www.wjgnet.com/1007-9327/full/v27/i30/5019.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i30.5019