Circular RNA AKT3 governs malignant behaviors of esophageal cancer cells by sponging miR-17-5p

Figure 1 Circular RNA AKT3 promoted malignant phenotypes of TE-1 cells. A: The expression of circular RNA AKT3 (circAKT3) in tissue samples; B: The expression of circAKT3 human normal esophageal epithelial cell line (HEEC) and human esophageal cancer cell lines; C and D: TE-1 cells were transfected with control oligo and circAKT3 siRNAs in the presence or absence of RNase R to detect the expression of circAKT3 and AKT3; E: The expression of circAKT3 in TE-1 cells with circAKT3 overexpression (OE); F: Cell viability of TE-1 cells as detected by the Cell Counting Kit-8 assay was performed to detect cell viability of TE-1 cells with indicated transfection; G: Migratory capacity of TE-1 cells with circAKT3 OE and knockdown; H: Invasive ability of TE-1 cells with circAKT3 OE and knockdown; I: Apoptosis of TE-1 cells with circAKT3 OE and knockdown by Hoechst staining. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. NC: Negative control; OD: Optical density.