Poor performance of anti-mitochondrial antibodies for the diagnosis of primary biliary cholangitis in female Colombian patients: A single-center study

Table 2 Sensitivity, specificity and predictive values of each antibody or antibody combination, for the diagnosis of primary biliary cholangitis

Antibody or antibody combination	Sensitivity	Specificity	PPV	NPV
AMA (+)	44.2	76.2	65.5	57.1
ANA (+)	74.4	38.1	55.2	59.3
ASMA (+)	14.0	73.8	35.3	45.6
IgG (+)	26.7	80.0	66.7	42.1
IgM (+)	57.1	85.7	92.3	40.0
AMA (+), ANA (+)	25.6	83.3	61.1	52.2
AMA (+), ANA (-)	18.6	92.9	72.7	52.7
AMA (-), ANA (+)	48.8	54.8	52.5	51.1
AMA (+), ASMA (+)	7.0	100	100	51.2
AMA (+), ASMA (-)	37.2	76.2	61.5	54.2
AMA (-), ASMA (+)	7.0	73.8	21.4	43.7
ANA (+), ASMA (+)	9.3	83.3	36.4	47.3
ANA (+) , ASMA (-)	65.1	54.8	59.6	60.5
ANA (-), ASMA (+)	4.7	90.5	33.3	48.1
AMA (+), IgG (+)	13.3	90.0	66.7	40.9
AMA (+), IgG (-)	46.7	70.0	70.0	46.7
AMA (-), IgG (+)	13.3	90.0	66.7	40.9
AMA (+), IgM (+)	52.4	85.7	91.7	37.5
AMA (+), IgM (-)	4.8	71.4	33.3	20.0
AMA (-), IgM (+)	4.8	100	100	25.9

AMA: Anti-mitochondrial antibodies; ANAs: Anti-nuclear antibodies; ASMA: Anti-smooth muscle antibodies; NPV: Negative predictive value; IgG: Immunoglobulin G; IgM: Immunoglobulin M; PPV: Positive predictive value.