Modulation of cell physiology under hypoxia in pancreatic cancer

doi:10.3748/wjg.v27.i28.4582

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 28, 2021; 27(28): 4582-4602
Published online Jul 28, 2021. doi: 10.3748/wjg.v27.i28.4582

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Figure 3 Contribution of mitogen-activated protein kinase signaling to cell responses under hypoxia. Mitogen-activated protein kinases comprise of a family of proteins that regulate physiological processes such as cell proliferation, differentiation, and survival, which play major roles in cancer development and progression. Differential inhibition of protein kinases might be used to attenuate the progression of the disease. Created with BioRender.com. ERK5: Extracellular-signal-regulated kinase 5; JNK: c-Jun amino-terminal kinase; MAPKs: Mitogen-activated protein kinases; PC: Pancreatic cancer; PSC: Pancreatic stellate cells.

Citation: Estaras M, Gonzalez A. Modulation of cell physiology under hypoxia in pancreatic cancer. World J Gastroenterol 2021; 27(28): 4582-4602
URL: https://www.wjgnet.com/1007-9327/full/v27/i28/4582.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i28.4582