Minimally invasive image-guided therapy of primary and metastatic pancreatic cancer

Table 5 Active pancreas irreversible electroporation clinical trials (source: ClinicalTrials.gov)

Title	Location	Hyperlink	Patients	Estimated completion
An open-label, multicenter, prospective study of IRE (Nano Knife) combined with radiotherapy and chemotherapy in patients with LAPC	Shanghai, China	https://clinicaltrials.gov/ct2/show/NCT04310553	40	December, 2020
Ablation of unresectable LAPC with IRE system	Teaneck, New Jersey, United States	https://clinicaltrials.gov/ct2/show/NCT03614910	30	May, 2023
Chemotherapy followed by irreversible electroporation in patients with unresectable LAPC	Aalborg, Denmark	https://clinicaltrials.gov/ct2/show/NCT04093141	30	May, 2024
Chemotherapy and IRE in the treatment of advanced pancreatic adenocarcinoma	Louisville, Kentucky, United States	https://clinicaltrials.gov/ct2/show/NCT03484299	20	December, 2023
PANFIRE-3 trial: Assessing safety and efficacy of IRE + Nivolumab + CpG for metastatic pancreatic cancer	Amsterdam, North-Holland, Netherlands	https://clinicaltrials.gov/ct2/show/NCT04612530	18	October, 2022
Outcomes of ablation of unresectable pancreatic cancer using the nanoknife IRE system	Baltimore, Maryland, United States	https://clinicaltrials.gov/ct2/show/NCT02041936	12	December, 2021
Immunotherapy and IRE in the treatment of advanced pancreatic adenocarcinoma	Louisville, Kentucky, United States	https://clinicaltrials.gov/ct2/show/NCT03080974	10	April, 2022
A study of the use of IRE in pancreatic ductal cancer	Toronto, Ontario, Canada	https://clinicaltrials.gov/ct2/show/NCT03257150	47	September, 2021
Safety and efficacy of IRE for LAPC	Seoul, Korea, Republic of	https://clinicaltrials.gov/ct2/show/NCT02898649	100	August, 2019
IRE (Nano Knife) for the treatment of pancreatic adenocarcinoma	Poitiers, France	https://clinicaltrials.gov/ct2/show/NCT03105921	20	June, 2020
IRE for inoperable hepatic and pancreatic malignancy	Hong Kong	https://clinicaltrials.gov/ct2/show/NCT02822716	35	December, 2021
Phase II/III of randomized controlled clinical research on IRE synchronous chemotherapy for LAPC	Guangzhou, Guangdong, China	https://clinicaltrials.gov/ct2/show/NCT03673137	120	November, 2021
Anti-tumor immunity induced by IRE of unresectable pancreatic cancer	Guangzhou, Guangdong, China	https://clinicaltrials.gov/ct2/show/NCT02343835	20	January, 2025
A pivotal study of safety and effectiveness of Nano Knife IRE for stage 3 pancreatic cancer	USA, Multicentre	https://clinicaltrials.gov/ct2/show/NCT03899636	528	December, 2023
Immunologic signatures following surgery for pancreatic cancer	Durham, North Carolina, United States	https://clinicaltrials.gov/ct2/show/NCT03001518	30	April, 2027

IRE: Irreversible electroporation; LAPC: Locally advanced pancreatic cancer.