Ubiquitin-specific protease 15 contributes to gastric cancer progression by regulating the Wnt/β-catenin signaling pathway

Figure 1 Ubiquitin-specific protease 15 is upregulated in gastric cancer cells and tissues, and is associated with a poor prognosis in gastric cancer patients. A: Frequency of ubiquitin-specific protease 15 (USP15) in various cancers, including gastric cancer (GC). The data were derived from the cBioPortal for Cancer Genomics; B, C: USP15 mRNA expression level of cancer tissue and normal tissue in GC. Analysis of The Cancer Genome Atlas data from TIMER and UALCAN databases; D: Protein expression of USP15 in GES-1 cell line and GC cell lines; E: Protein expression of USP15 in GC tissue and adjacent noncancerous tissues (n = 8); F, G: Representative images of immunohistochemical staining of USP15 in human GC tissues and adjacent noncancerous tissues; H: USP15 staining scores of GC and normal tissues; I: Correlation between USP15 expression level and overall survival (OS) in GC patients obtained from Kaplan–Meier Plotter databases (209475_at, HR = 2.07 (1.43-3), log rank P = 8.5e⁻⁰⁵); J: Kaplan–Meier curve stratified by USP15 expression in 115 GC patients (log-rank test, P = 0.0006). ^bP < 0.01, data were expressed as the mean ± standard error of the mean.