Metal-organic framework IRMOFs coated with a temperature-sensitive gel delivering norcantharidin to treat liver cancer

Figure 5 Apoptosis rates of Hepa1-6 cells after 48 h. Apoptosis rates of norcantharidin (NCTD)-loaded metal-organic framework IRMOF-3 coated with temperature-sensitive gel (NCTD-IRMOF-3-Gel) at the high concentration (C) and low concentration (F) were 32.11 μg/mL and 65.60 μg/mL, respectively. Compared with the NCTD control group, the apoptosis rate in the NCTD-IRMOF-3-Gel group was highest, which indicated that NCTD-IRMOF-3-Gel could induce the apoptosis of Hepa1-6 cells. A: 50 μg/mL NCTD-IRMOF-3; B: 50 μg/mL NCTD; C: 50 μg/mL NCTD-IRMOF-3-Gel; D: 25 μg/mL NCTD-IRMOF-3; E: 25 μg/mL NCTD; F: 25 μg/mL NCTD-IRMOF-3-Gel.