Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket?

doi:10.3748/wjg.v27.i26.4045

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 14, 2021; 27(26): 4045-4087
Published online Jul 14, 2021. doi: 10.3748/wjg.v27.i26.4045

Table 8 Biliary fluid diagnostic biomarkers studied with relation to pancreatic cancer

Type	Candidate marker
Protein	VEGF[217,429], CA19-9[431], CA125[432], CA72-4[432], CEA[432,433], sLR11[434], MUC4[435], IGF-1[217,430], NGAL[436-439], CEAM6[436,440], LG3BP[436], MMP7[436], MUC5B[436], MCM5[441,442], Trypsinogen-1[443], Trypsinogen-2[443]
Liquid biopsy	Methylated DNA: TFP12[444], NPTX2[444], CCND2[444]
RNA	MiRNA: miR-10b[292,445], miR-106b[292,445], miR-30c[292,445], miR-155[292,445], miR-212[292,445], miR-1247[446], miR-200a[446], miR-200b[446]

MCM5: Minichromosome maintenance protein 5; NGAL: Neutrophil gelatinase-associated lipocalin; sLR11: Soluble LDL receptor relative with 11 ligand-binding repeats; IGF1: Insulin-like growth factor 1; LG3BP: Galectin-3-binding protein; CEAM6: Carcinoembryonic cell adhesion molecule 6; TFP12: Methylated tissue factor pathway inhibitor 2; NPTX2: Neuronal pentraxin II gene; CCND2: G1/S-specific cyclin-D2; VEGF: Vascular endothelial growth factor; CEA: Carcinoembryonic antigen; MiRNA: MicroRNA.

Citation: O'Neill RS, Stoita A. Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket? World J Gastroenterol 2021; 27(26): 4045-4087
URL: https://www.wjgnet.com/1007-9327/full/v27/i26/4045.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i26.4045