Zinc oxide nanoparticles reduce the chemoresistance of gastric cancer by inhibiting autophagy

Figure 7 Zinc oxide nanoparticle reduces the tumor growth of chemoresistant gastric cancer cells in vivo. The impact of zinc oxide nanoparticle (ZnO-NP) on tumor growth of cisplatin (DDP)-resistant gastric cells in vivo was analyzed by the nude mice tumorigenicity assay (n = 5). SGC7901/DDP cells were treated with ZnO-NP (5 μg/mL) or an equal volume of saline. A: Representative images of dissected tumors from nude mice are shown; B: The average tumor volume was calculated; C: The average tumor weight was calculated. Data are presented as the mean ± SD. Statistic significant differences are indicated: ^bP < 0.01.