Zinc oxide nanoparticles reduce the chemoresistance of gastric cancer by inhibiting autophagy

Figure 3 Zinc oxide nanoparticle attenuates the chemotherapy drug resistance of gastric cancer cells. A: SGC7901/cisplatin (DDP) cells were treated with DDP at the indicated doses and treated with zinc oxide nanoparticle (ZnO-NP, 5 μg/mL) or an equal volume of saline. Cell viability was measured by the MTT assay; B and C: SGC7901/DDP cells were treated with DDP or co-treated with DDP and ZnO-NP (5 μg/mL). Cell apoptosis was assessed by flow cytometry. Data are presented as the mean ± SD. Statistically significant differences are indicated: ns, no significance, ^aP < 0.05. FITC: Fluorescein isothiocyanate.