Endoscopic submucosal dissection vs endoscopic mucosal resection for colorectal polyps: A meta-analysis and meta-regression with single arm analysis

Table 1 Pooled proportions and comparative meta-analysis of endoscopic submucosal dissection and endoscopic mucosal resection

	Total papers	Sample size (ESD)	Pooled proportions	Sample size (EMR)	Pooled proportions	RR (CI)	P value	Publication bias
En bloc resection	11	1641	89% (0.83-0.94)	1411	47% (0.36-0.59)	1.837 (1.464-2.305)	< 0.001	0.0025
Positive lateral margin	2	123	3% (0.01-0.06)	187	14% (0.09-0.19)	0.292 (0.089-0.995)	0.042	-
Positive vertical margin	1	38	5% (0.00-0.17)	83	1% (0.00-0.07)	4.368 (0.409-46.710)	0.223	-
Complete resection	8	918	82% (0.74-0.88)	1012	56% (0.34-0.77)	1.504 (1.041-2.174)	0.03	-
Lymphovsacular invasion	1	54	6% (0.03-0.13)	23	0% (0.00-0.04)	4.352 (0.248-76.483)	0.315	-
Mean procedural time	8	1087	-	838	-	72.709 (54.487-90.931)	< 0.001	-
Additional surgery	2	99	13% (0.07-0.21)	153	5% (0.02-0.09)	3.139 (1.360-7.243)	0.007	-
Perforation	18	19470	5% (0.03-0.09)	260901	0% (0.00-0.01)	7.597 (4.281-13.479)	< 0.001	0.301
Bleeding	14	20048	3% (0.02-0.05)	257065	3% (0.02-0.04)	1.277 (0.896-1.820)	0.175	0.139
Recurrences	12	1822	2% (0.01-0.03)	37721	10% (0.04-0.17)	0.269 (0.112-0.648)	0.003	0.725

ESD: Endoscopic submucosal dissection; EMR: Endoscopic mucosal resection; CI: Confidence interval.