Clinical characteristics of patients in their forties who underwent surgical resection for colorectal cancer in Korea

Table 3 Pathology data

	30s (n = 120)	40s (n = 451)	50s (n = 1044)	P value1	P value2	P value3	P value4
pT (%)				0.251	0.986	0.214	0.446
Tis	6.7	5.8)	8.1
T0	5.0	4.0	4.0
T1	9.2	6.4	10.8
T2	12.5	12.0	13.6
T3	55.0	62.5	54.8
T4	11.7	9.3	8.3
Unknown	0	0	0.3
pN (%)				0.419	0.289	0.831	0.521
N0	56.7	50.8	57.2
N1	24.2	28.2	25.3
N2	16.7	17.7	14.1
Unknown	2.5	3.3	3.4
Positive LN, mean (n)	1.9	1.8	1.8	0.709	0.960	0.803	0.958
Retrieved LN, mean (n)	34	29	27	0.030	0.015	< 0.001	< 0.001
M (%)				0.438	0.003	0.386	0.012
M0	81.7	78.3	84.8
M1	17.5	21.1	14.9
Unknown	0.8	0.7	0.3
Stage (%)				0.138	< 0.001	0.613	0.002
0	11.7	8.6	11.3
1	15.8	13.1	18.6
2	28.3	27.1	25.7
3	26.7	29.3	28.3
4	17.5	21.1	14.8
Unknown	0	0.9	1.3
Tumor size, mean (cm)	4.9	4.7	4.3	0.797	0.079	0.207	0.125
PRM, mean (cm)	19.2	16.6	16.3	0.044	0.699	0.395	0.530
DRM, mean (cm)	6.7	6.0	6.8	0.431	0.205	0.690	0.412
CRM, mean (cm)	0.6	0.7	0.7	0.856	0.834	0.681	0.927
Differentiation (%)				0.279	0.670	0.155	0.347
Well	22.5	17.5	18.6
Moderate	56.7	68.3	67.0
Poor	5.0	2.9	2.4
Mucinous	7.5	5.1	4.7
Signet ring cell	0.8	0	0.3
Etc.	0.8	0	0.1
Unknown	6.7	6.2	6.9
Venous invasion (%)	8.3	5.1	4.9	0.159	0.893	0.101	0.254
Lymphatic invasion (%)	20.0	15.3	16.8	0.194	0.432	0.365	0.415
Perineural invasion (%)	13.3	9.5	7.9	0.199	0.297	0.036	0.094
IHC (% positive)
EGFR	53/63 (84.1)	210/274 (76.6)	506/673 (75.2)	0.197	0.636	0.113	0.275
CDX-2	23/24 (95.8)	84/87 (96.6)	236/239 (98.7)	0.869	0.194	0.268	0.338
P53	50/52 (96.2)	217/223 (97.3)	549/572 (96.0)	0.657	0.369	0.951	0.668
MLH-1	31/33 (93.9)	162/165 (98.2)	398/407 (97.8)	0.158	0.767	0.174	0.326
MSH-2	33/33 (100)	165/165 (100)	403/408 (98.8)	-	0.154	0.524	0.295
MSH-6	24/24 (100)	118/120 (98.3)	292/295 (98.9)	0.528	0.583	0.621	0.738
PMS-2	19/20 (95)	97/100 (97)	240/249 (96.4)	0.652	0.777	0.754	0.899
BRAF	3/19 (15.8)	3/63 (4.8)	7/180 (3.9)	0.108	0.765	0.024	0.076
Molecular test (% wild-type)
K-ras	17/33 (51.5)	92/138 (66.7)	152/274 (55.5)	0.105	0.029	0.667	0.064
N-ras	20/21 (95.2)	90/95 (94.7)	193/200 (96.5)	0.926	0.475	0.770	0.768
Braf	12/12 (100)	51/53 (96.2)	93/97 (95.9)	0.502	0.917	0.478	0.778
MSI
MSS	14/18 (77.8)	59/67 (88.1)	142/163 (87.1)	0.271	0.846	0.278	0.506
MSI-L	1/18 (5.6)	2/67 (3.0)	15/163 (9.2)	0.605	0.102	0.607	0.248
MSI-H	3/18 (16.7)	6/67 (9.0)	6/163 (3.7)	0.351	0.103	0.016	0.046

¹30s vs 40s.

²40s vs 50s.

³30s vs 50s.

⁴30s vs 40s vs 50s. LN: Lymph node; PRM: Proximal resection margin; DRM: Distal resection margin; CRM: Circumferential resection margin; IHC: Immunohistochemistry; EGFR: Epidermal growth factor receptor; MSI: Microsatellite instability.