PPARGC1A rs8192678 G>A polymorphism affects the severity of hepatic histological features and nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease

Table 7 Biochemical and genetic characteristics of patients with nonobese nonalcoholic fatty liver disease

Variables	NAFL (n = 6)	NASH (n = 12)	P value
Sex (M/F)	4/2	10/2	0.569
Age (year)	35.33 ± 18.44	39.67 ± 4.80	0.452
BMI (kg/m2)	22.83 ± 1.61	23.69 ± 0.90	0.122
ALP (U/L)	123.32 ± 77.62	84.25 ± 23.28	0.426
GGT (U/L)	28.50 (21.18-85.00)	73.25 (54.75-99.25)	0.068
ALT (U/L)	42.00 (21.78-78.50)	71.15 (41.10-115.25)	0.325
TC (mmol/L)	5.11 ± 0.55	4.96 ± 1.02	0.606
TG (mmol/L)	2.00 ± 0.43	1.77 ± 0.95	0.371
HDL-C (mmol/L)	1.10 ± 0.16	1.24 ± 0.44	0.943
LDL-C (mmol/L)	3.16 ± 0.46	2.82 ± 0.80	0.524
FBG (mmol/L)	5.03 ± 0.94	5.24 ± 0.85	0.587
UA (μmol/L)	360.86 ± 167.34	354.17 ± 67.43	0.684
CAP (dB/m)	257.00 ± 57.03	316.73 ± 43.48	0.056
LSM (kPa)	6.95 ± 4.07	6.79 ± 2.06	0.421
PPARGC1A rs8162678
GG, n (%)	4 (66.67)	1 (8.33)
GA + AA, n (%)	2 (33.33)	11 (91.67)	0.021
PNPLA3 rs738409
CC, n (%)	2 (33.33)	1 (8.33)
CG + GG, n (%)	4 (66.67)	11 (91.67)	0.245

The data are expressed as mean ± SD, or as n (%) for normally distributed variables and as median (interquartile range) when distribution of the variable was skewed. NAFL: Nonalcoholic fatty liver; NASH: Nonalcoholic steatohepatitis; BMI: Body mass index; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; GGT: γ-glutamyl transpeptidase; TC: Total cholesterol; TG: Total triglycerides; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; FBG: Fasting blood glucose; UA: Uric acid; LSM: Liver stiffness measurement; CAP: Controlled attenuation parameter; PNPLA3: Patatin-like phospholipase domain-containing protein 3.