PPARGC1A rs8192678 G>A polymorphism affects the severity of hepatic histological features and nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease

Table 6 Association of the PPARGC1A genotypes with steatosis, activity, and fibrosis in patients with nonalcoholic fatty liver disease

Histological features		Genotypes		Dominant model		Multivariate analysis1
		GG (n = 14)	GA + AA (n = 45)	P value	OR (95%CI)	P value	OR (95%CI)
Steatosis (S)	S1	10 (71.43%)	15 (33.33%)
	S2-3	4 (28.57%)	30 (66.67%)	0.012	5.000 (1.343-18.620)	0.011	6.190 (1.508-25.410)
Activity (A)	A < 2	6 (42.86%)	7 (15.56%)
	A ≥ 2	8 (57.14%)	38 (84.44%)	0.031	4.071 (1.076-15.402)	0.040	4.506 (1.070-18.978)
Significant fibrosis	F0-1	12 (85.71%)	28 (62.22%)
	F2-4	2 (14.29%)	17 (37.78%)	0.100	3.643 (0.726-18.292)	0.186	3.449 (0.551-21.598)
Advanced fibrosis	F0-2	13 (92.86%)	35 (77.78%)
	F3-4	1 (7.14%)	10 (22.22%)	0.206	3.714 (0.432-31.949)	0.426	2.549 (0.255-25.490)
NASH	NAFL	9 (64.28%)	13 (28.89%)
	NASH	5 (35.71%)	32 (71.11%)	0.017	4.431 (1.245-15.763)	0.035	6.337 (1.135-35.392)

¹Multivariate analysis adjusted for age, sex, body mass index, and patatin-like phospholipase domain-containing protein 3 rs738409 risk G allele. NAFL: Nonalcoholic fatty liver; NASH: Nonalcoholic steatohepatitis; OR: Odds ratio; CI: Confidence interval.