PPARGC1A rs8192678 G>A polymorphism affects the severity of hepatic histological features and nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease

Table 4 Association tests of PPARGC1A rs8192678 polymorphism between different groups

PPARGC1A rs8192678	Case			Control			Dominant model
	GG	GA	AA	GG	GA	AA	χ2	P value	OR (95%CI)
NAFLD vs Control	14	37	8	39	37	17	5.269	0.022	2.321 (1.121-4.806)
NASH vs Control	5	28	4	39	37	17	9.550	0.002	4.622 (1.653-12.929)
NASH vs NAFL	5	28	4	9	9	4	5.721	0.017	4.431 (1.245-15.763)
Obese vs nonobese participants	17	33	10	36	41	15	1.864	0.172	1.626 (0.807-3.276)
Obese NAFLD vs nonobese NAFLD	9	27	5	5	10	3	0.235	0.628	1.368 (0.384-4.865)
Obese NASH vs nonobese NASH	4	19	2	1	9	2	0.408	0.348	0.477 (0.047-4.806)
Obese NAFL vs nonobese NAFL	5	8	3	4	1	1	2.264	0.132	4.400 (0.596-32.501)
Obese NASH vs obese NAFL	4	19	2	5	8	3	1.324	0.250	2.386 (0.531-10.734)
Nonobese NASH vs nonobese NAFL	1	9	2	4	1	1	6.785	0.021	22.000 (1.540-314.292)

NAFL: Nonalcoholic fatty liver; NASH: Nonalcoholic steatohepatitis; NAFLD: Nonalcoholic fatty liver disease; OR: Odds ratio; CI: Confidence interval.