PPARGC1A rs8192678 G>A polymorphism affects the severity of hepatic histological features and nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease

Table 3 Genotype distribution of PPARGC1A rs8192678 and patatin-like phospholipase domain-containing protein 3 rs738409 in patients with nonalcoholic fatty liver disease and controls

Genotype	NAFLD (n = 59)	Controls (n = 93)	χ2	P value	OR (95%CI)
PPARGC1A rs8192678
GG	14 (23.73%)	39 (41.94%)
GA	37 (62.71%)	37 (39.78%)	7.148	0.008	2.786 (1.300-5.962)
AA	8 (13.56%)	17 (18.28%)	0.262	0.609	1.311 (0.464-3.704)
GA+AA	45 (76.27%)	54 (58.06%)	5.269	0.022	2.321 (1.121-4.806)
PNPLA3 rs738409
CC	12 (20.34%)	35 (37.63%)
CG	27 (45.76%)	43 (46.24%)	2.152	0.142	1.831 (0.812-4.131)
GG	20 (33.90%)	15 (16.13%)	8.423	0.004	3.889 (1.524-9.926)
CG + GG	47 (79.56%)	58 (62.37%)	5.055	0.025	2.364 (1.105-5.055)

OR: Odds ratio; CI: Confidence interval; PNPLA3: Patatin-like phospholipase domain-containing protein 3; NAFLD: Nonalcoholic fatty liver disease.