PPARGC1A rs8192678 G>A polymorphism affects the severity of hepatic histological features and nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease

Table 2 Clinical characteristics of patients with nonalcoholic steatohepatitis and nonalcoholic fatty liver among patients with nonalcoholic fatty liver disease

Variable	NAFL (n = 22)	NASH (n = 37)	P value
Sex (M/F)	17/5	26/11	0.559
Age (year)	37.23 ± 13.64	38.78 ± 14.01	0.605
BMI (kg/m2)	27.07 ± 3.69	27.38 ± 3.17	0.675
ALP (U/L)	102.96 ± 52.34	93.56 ± 39.91	0.982
GGT (U/L)	38.00 (23.80-69.03)	69.70 (39.00-85.50)	0.023
ALT (U/L)	46.00 (30.33-64.95)	71.40 (46.9-111.70)	0.006
TC (mmol/L)	5.03 ± 1.04	4.76 ± 0.72	0.801
TG (mmol/L)	1.91 ± 0.74	2.04 ± 1.48	0.532
HDL-C (mmol/L)	1.21 ± 0.28	1.19 ± 0.28	0.903
LDL-C (mmol/L)	2.97 ± 0.91	2.72 ± 0.49	0.444
FBG (mmol/L)	6.43 ± 3.59	5.62 ± 1.77	0.318
UA (μmol/L)	360.91 ± 107.80	361.62 ± 106.22	0.482
CAP (dB/m)	295.50 (249.25-345.00)	333.00 (296.25-356.25)	0.038
LSM (kPa)	6.20 (4.55-9.95)	9.60 (6.50-12.85)	0.008
Obesity, n (%)	16 (72.73)	25 (60.97)	0.677
Hypertension, n (%)	8 (36.36)	14 (37.84)	0.910
T2DM, n (%)	3 (13.64)	4 (10.81)	0.746

The data are expressed as mean ± SD, or as n (%) for normally distributed variables and as median (interquartile range) when distribution of the variable was skewed. NAFL: Nonalcoholic fatty liver; NASH: Nonalcoholic steatohepatitis; BMI: Body mass index; ALP: Alkaline phosphatase; GGT: γ-glutamyl transpeptidase; ALT: Alanine aminotransferase; TC: Total cholesterol; TG: Triglycerides; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; FBG: Fasting blood glucose; UA: Uric acid; LSM: Liver stiffness measurement; CAP: Controlled attenuation parameter; T2DM: Type 2 diabetes mellitus.