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Copyright ©The Author(s) 2021.
World J Gastroenterol. Jul 7, 2021; 27(25): 3790-3801
Published online Jul 7, 2021. doi: 10.3748/wjg.v27.i25.3790
Table 1 Immune repertoire investigation of hepatitis B virus infection
Number
Ref.
Patients
Amounts of samples
Repertoire
Sequencing reads
Tools
1Deulofeut et al[59], 19972 volunteers2TCR repertoire-PRISM
2Höhn et al[60], 2002Healthy individuals immunized with recombinant hepatitis B surface antigen7TCR-VA and -VB repertoire in CD8+ T cells-FITC/PE
3Soroosh et al[69], 2003Nine healthy adult responders and six nonresponders30TCR beta chain variable geneFRAGMENT MANAGER’ software program
4Yang et al[41], 2011Forty-two patients with CSHB42TCR CDR3-SPSS 16.0 software
5Xiong et al[44], 201418 patients with CSHB and 8 controls26TCR Vβ repertoire-DNAMAN software version 1.0
6Han et al[52], 2015Liver cancers and healthy adults160TCR CDR3495708702BLAST
7Galson et al[62], 2015Naïve group: n = 9; vaccine group: n = 9108B-cell repertoire365863R
8Qu et al[37], 20164 CHB patients before and after HBeAg seroconversion8TCR Vβ repertoire370210 to 685596Homemade Perl script
9Yang et al[55], 201612 HBeAg SC patients and 20 no HBeAg SC patients96TCRBV families-SPSS software version 19.0
10Galson et al[63], 20169 healthy subjects63B-cell repertoireR
11Chang et al[70], 20164 pairs of HBeAg positive carrier and HBsAg negative non-carrier siblings16IgG immune repertoire2.2 millionPEAR, Python, Numpy and SciPy, Ipython
12Ma et al[64], 20173 healthy volunteers6IgM and IgG H chain CDR3 repertoiresIMGT/High V-Quest
13Jiang et al[36], 20183 pairs of healthy identical twins and 7 pairs of chronic hepatitis B patients20CD8+ T-cell receptor beta (TCRβ) chains50 millionMIXCR
14Yan et al[49], 20196 patients with HBV-related ACLF and 6 controls12BCR CDR3 regionAn average number of 12243860.30 in the control group and an average number of 1229965.30 in the ACLF groupGraphPad Prism software
15Miyasaka et al[61], 20195 volunteers30T-cell and B-cell receptor repertoireTCR β chain repertoire was 153151 before HB vaccination, 180093 after the second HB vaccination, and 129044 the third HB vaccination; BCR IgG heavy (H) chain repertoires were 106664 before HB vaccination, 126237 after the second HB vaccination, and 135663 the third HB vaccinationSPSS software package, Easy R (EZR) version 1.37, GraphPad software package
16Shen et al[48], 20205 HBV-ACLF20TCR repertoire163259321MIXCR
17Lian et al[57], 202020 CHB patients undergoing 1-yr ETV treatment (10 HBeAg SC patients and 10 no HBeAg SC patients)60T-cell repertoire-MIXCR