Review
Copyright ©The Author(s) 2021.
World J Gastroenterol. Jul 7, 2021; 27(25): 3762-3779
Published online Jul 7, 2021. doi: 10.3748/wjg.v27.i25.3762
Table 1 Studies investigating hepatitis B virus prevalence in inflammatory bowel disease patients
Ref.Type of study; CountryPatientsHBsAg-positiveAnti-HBc-positiveAnti-HBs-positiveComments
Losurdo et al[33], 2020Single-center cohort; Italy807 IBD0.9%7.7%Similar to regional prevalence
438 CD
369 UC
Fousekis et al[31], 2019Retrospective single-center; Greece602 IBD5.3%13.4%32.4%Similar to regional prevalence
Silva et al[94], 2019Cross-sectional; Brazil306 IBD0.7%Similar to regional prevalence
165 UC
141CD
Chou et al[95], 2019Retrospective; Taiwan190 IBD13.3%Higher prevalence of HBsAg in IBD
80 CD
110 UC
Yeo et al[96], 2018Prospective cohort; Korea210 IBD3.8%26.2%Treatment-naïve similar prevalence
109 UC
101 CD
Chen et al[35], 2017Retrospective; China980 IBD7.9%41.2%46.6%Higher prevalence of HBsAg in IBD
334 UC8.1%52.7%48.8%
646 CD7.7%35.3%45.5%
Harsh et al[34], 2017Retrospective; India908 IBD2.4%Similar to regional prevalence
581 UC2.2%
327CD2.8%
Waszczuk et al[32], 2016Prospective cross-sectional; Poland147 IBD14.3%Similar to regional prevalence
Chan et al[97], 2016Retrospective cohort; China406 IBD5.7%Similar to regional prevalence
He et al[98], 2015Retrospective; China449 CD13.6%25.4%31.2%Similar to regional prevalence
226 UC16.8%30.1%24.3%
Ben Musa et al[47], 2014Retrospective observational; United States500 IBD1.8%3.2%Similar to regional prevalence (screening rate 51%)
Huang et al[99], 2014Retrospective; China714 IBD5.5%40.6%21.6%Higher prevalence of HBsAg in IBD patients
Kim et al[37], 2014Observational; Korea513 IBD3.7%Similar to regional prevalence
241 CD4.1%
272 UC3.3%
Papa et al[28], 2013Prospective; Italy301 IBD0.3%7.3%Similar to regional prevalence
Park et al[93], 2012Retrospective; Korea4153 IBD4.1%Similar to regional prevalence
1521 CD3.6%
1728 UC4.6%
Katsanos et al[30], 2010Retrospective; Greece482 IBD2.3%Similar to regional prevalence
Chevaux et al[100], 2010Hospital-based; France315 IBD48.9%Similar to regional prevalence
252 CD0.8%2.8%
63 UC1.6%1.6%
Loras et al[101], 2009Multicenter Hospital-based; Spain2076 IBDSimilar to regional prevalence
1128 CD0.6%7.1%17%
928 UC0.8%8%14.9%
20 IC05.3%17.6%
Tolentino et al[27], 2008Hospital-based; Brazil102 CD043.3%Higher prevalence of anti-HBc patients
74 UC2.3%56.7%
Esteve et al[102], 2004Multicenter; Spain80 CD7.5%Screening prior to anti-TNF treatment
Biancone et al[26], 2001Multicenter; Italy332 CD2.1%10.9%14.4%Higher prevalence of HBsAg in IBD
162 UC0.6%11.5%15.8%