Fasudil prevents liver fibrosis via activating natural killer cells and suppressing hepatic stellate cells

Figure 1 Fasudil protects thioacetamide-induced liver injury. A: Establishment of a liver fibrosis mouse model; B: Representative detection of liver images is shown. Gross pathological examination of liver taken from normal control, thioacetamide (TAA)-treated, and TAA + Fasudil-treated groups, and the liver/body ratio was assayed among these three groups; C: Histological observation of liver fibrosis by hematoxylin and eosin staining under light-field microscope with × 100 magnification; D: Enzyme-linked immunoassay was used to assess the level of serum alanine aminotransferase and aspartate aminotransferase. Data represent the mean ± SD from at least three independent experiments (n = 5/group). ^aP < 0.05, ^bP < 0.01.