Natural killer cells in pancreatic cancer stroma

Figure 3 Leukocyte function-associated antigen 1 conformation. Leukocyte function-associated antigen 1 (LFA-1) affinity can be altered by its conformation. When bent, LFA-1 exhibits low affinity for its ligand, ICAM1. Intermediate affinity is achieved through a closed/extended conformation, whilst an open/extended conformation results in high affinity binding to ICAM1 and generation of an effective, stable immunological synapse.