Stem cell injection for complex anal fistula in Crohn’s disease: A single-center experience

Table 3 Patient population

	1	2	3	4	5	6	7	8	9	10	11	12
Age	26 yr	31 yr	52 yr	49 yr	39 yr	35 yr	61 yr	26 yr	54 yr	44 yr	45 yr	48 yr
Sex	Male	Female	Female	Female	Male	Female	Male	Female	Male	Male	Male	Female
CPF Parks classification (number of fistulas)	Transsphincteric (2)	Transsphincteric (2)	Suprasphincteric (1)	Transsphincteric (2)	Transsphincteric (1) Intersphincteric (1)	Transsphincteric (2)	Transsphincteric (2)	Transsphincteric (1)	Suprasphincteric (1) Transsphincteric (1)	Transsphincteric horse-shoe-fistula (2)	Transsphincteric horse-shoe-fistula (2)	Suprasphincteric (1)
Number of internal/external openings	2/2	2/2	1/1	2/2	2/2	1/2	2/2	1/1	2/2	1/2	1/2	1/1
Length of fistula tract	3 cm each	3 cm each	4 cm	2 cm; 5 cm	10 cm; 1.5 cm	12 cm; 1.5 cm	3 cm; 7 cm	3 cm	6.5 cm; 2.5 cm	2.5 cm; 2.5 cm	3.0 cm; 3.0 cm	3.0 cm
Previous medical treatment	Azathioprin	Azathioprin Infliximab	Azathioprin	Azathioprin	Azathioprin	Azathioprin	Azathioprin Infliximab	Azathioprin	Adalimumab	Azathioprin Adalimumab	Infliximab	Azathiopron Antibiotics
Actual medical treatment	Adalimumab	Ustekinumab	Azathioprin	None	Ustekinumab	Vedolizumab	Ustekinumab	Infliximab	Infliximab	Infliximab	Adalimumab	None
Previous surgical treatment for abscess and fistula	Multiple abscess excisions, previous fistula surgery (1)	Multiple abscess excisions, previous fistula surgery (1)	Multiple abscess excisions,previous fistula surgery (3)	Multiple abscess excisions, previous fistula surgery (2)	Multiple abscess excisions, previous fistula surgery (3)	Multiple abscess excisions, previous fistula surgery (2)	Multiple abscess and fistula surgeries (11)	Multiple abscess and fistula surgery (4)	Multiple abscess and fistula surgery (4)	Multiple abscess and fistula surgery (4)	Multiple abscess and fistula surgery (3)	Multiple abscess and fistula surgery (9)
Previous treatment (stoma)	No	Yes	No	Yes	No	No	No	No	No	Yes	Yes	No
Seton drainage prior to Darvadstrocel (duration)	Yes (6 wk)	Yes (4 mo)	Yes (10 mo)	Yes (18 mo)	Yes (8 wk)	Yes (12 wk)	Yes (9 mo)	Yes (60 wk)	Yes (36 wk)	Yes (48 wk)	Yes (24 wk)	Yes (12 wk)
Method of closure of internal opening	Suture (1), mucosal flap (1)	Suture (2)	Suture (1)	Suture (2)	Suture (2)	Suture (1)	Suture (2)	Suture (1)	Suture (2)	Suture (1)	Suture (1)	Suture (1)
Intraoperative adverse events	No	No	No	No	No	No	No	No	No	No	No	No
Postoperative adverse events	No	No	No	No	No	No	No	No	No	No	Fewer (day 2)	No

CD: Crohn’s disease; CPF: Crohn’s perianal fistula.