Oncogenic tuftelin 1 as a potential molecular-targeted for inhibiting hepatocellular carcinoma growth

Figure 5 Effects of tuftelin 1 on healing, invasion, and migration of hepatocellular carcinoma cells. A: The scratch test of the MHCC-97H cells, the cell healing ability was decreasing after the high tuftelin 1 (TUFT1) cells were transfected with the TUFT1-shRNA3 plasmid, and A1, the relative cell healing ability was significantly inhibited compared with the control or negative sh-RNA for tuftelin 1 mRNA (sh-NC) cells (^bP < 0.001); B: The scratch test of the Hep3B cells, the cell healing ability was increased after the cells were transfected with the over-expressing TUFT1 plasmid; B1, the relative cell healing ability was significantly improved compared with the control or blank control (NC) cells (^bP < 0.001); C: The migration and invasion abilities of the MHCC-97H cells were analyzed by the transwell test; C1: The histograms of the cell migration and invasion abilities among the different groups (^bP < 0.001): D: The migration and invasion abilities of the Hep3B cells were analyzed by the transwell test; D1: The histograms of the cell migration and invasion abilities among the different groups (^bP < 0.001). Data are presented as mean ± standard error of the mean of at least three independent experiments. sh-RNA: sh-RNA3 for tuftelin 1 mRNA.