Retrospective Cohort Study
Copyright ©The Author(s) 2021.
World J Gastroenterol. Jun 21, 2021; 27(23): 3372-3385
Published online Jun 21, 2021. doi: 10.3748/wjg.v27.i23.3372
Table 3 Factors associated with the survival time of acute-on-chronic liver failure patients based on Cox proportional hazards regression
Univariate
Multivariate
HR (95%CI)
P value
HR (95%CI)
P value
Gender0.58 (0.37-0.91)0.0190.535 (0.332-0.861)0.01
Age (yr)1 (0.99-1)0.23
WBC (109/L)1 (0.99-1.1)0.12
RBC (1012/L)0.73 (0.57-0.92)0.009
Hb (g/L)0.99 (0.98-1)0.01
PLT (109/L)0.99 (0.99-1)0.021
PT (s)1.1 (1-1.1)< 0.001
INR1.9 (1.4-2.5)< 0.0012.725 (1.949-3.811)< 0.001
ALT (U/L)1 (1-1)0.53
AST (U/L)1 (1-1)0.8
γ-GGT (U/L)1 (1-1)0.93
TBIL (μmol/L)1 (1-1)0.77
ALB (g/L)0.95 (0.9-1)0.079
Scr (μmol/L)1 (1-1)0.15
BUN (mmol/L)1.1 (1-1.2)0.0211.095 (1.025-1.170)0.0069
TCHO (mmol/L)1 (0.85-1.3)0.761.220 (1.006-1.170)0.0436
TG (mmol/L)0.78 (0.55-1.1)0.18
Na+ (mmol/L)0.94 (0.9-0.98)0.005
K+ (mmol/L)0.83 (0.58-1.2)0.34
AMON (μmol/L)1 (0.99-1)0.64
AFP (ng/ml)1 (1-1)0.075
BMI (kg/m2)0.99 (0.93-1.1)0.7
FBG (mmol/L)0.58 (0.39-0.87)0.0090.842 (0.719-0.986)0.0325
CTP1.7 (1-2.9)0.042
MELD1.1 (1-1.1)0.02
MELD-Na1 (1-1.1)0.002
DM2.4 (1.5-3.7)< 0.0013.17 (1.82-5.523)< 0.001
Ascites1.2 (1-1.5)0.036
HE1.3 (0.65-2.5)0.48
HRS3.3 (1.9-5.8)< 0.0012.71 (1.513-4.857)0.001
AUGIB2.6 (1.1-5.9)0.0272.444 (1.037-5.76)0.041
SBP2.5 (1.6-3.9)< 0.0012.262 (1.438-3.558)< 0.001
Other infections1.2 (0.82-1.9)0.32
γ-GGT: Gamma-glutamyl transpeptidase; AFP: Alpha fetal protein; ALB: Albumin; ALT: Alanine aminotransferase; AMMON: Ammonia; AST: Aspartate aminotransferase; AUGIB: Acute upper gastrointestinal bleeding; AUGIH: Acute upper gastrointestinal hemorrhage; BMI: Body mass index; BUN: Blood urea nitrogen; CI: Confidence interval; CTP: Child-Turcotte-Pugh; DM: Diabetic mellitus; FBG: Fasting blood glucose; HB: Hemoglobin; HE: Hepatic encephalopathy; HR: Hazard ratio; HRS: Hepatorenal syndrome; INR: International normalized ratio; Na+: Natriumion; K+: Kalium; MELD: Model for End-Stage Liver Disease; MELD-Na: Model for End-Stage Liver Disease with serum sodium; PLT: Platelet count; PT: Prothrombin time; RBC: Red blood cell; SBP: Spontaneous peritonitis; Scr: Serum creatinine; TBIL: Total bilirubin; TCHO: Total cholesterol; TG: Triglyceride; WBC: White blood cell.