Review
Copyright ©The Author(s) 2021.
World J Gastroenterol. Jun 21, 2021; 27(23): 3223-3237
Published online Jun 21, 2021. doi: 10.3748/wjg.v27.i23.3223
Table 2 Studies that used non-patented indices to estimate liver fibrosis in patients with hepatitis C virus infection and unhealthy alcohol use
Ref.
Setting
Non-invasive method
Method for detecting alcohol consumption
Finding
Lieber et al[87], 2006 Veterans' affairs studies (2) of alcoholic liver diseaseAPRI1Average alcohol intakeLow sensitivity and specificity of APRI in comparison to liver biopsy, especially in patients with HCV
Chaudhry et al[89], 2009 HIV Hopkins clinical cohortAPRI1Past 6 mo of hazardous drinkingNo effect of alcohol on APRI values in HCV/HIV co-infection
Blackard et al[90], 2011 WIHS cohortFIB-42Recent drinkingNo association between alcohol intake and FIB-4 values in HCV/HIV co-infection
Muga et al[92], 2012 Patients with AUD admitted for detoxification FIB-42Past 6 mo of unhealthy drinkingNo association between FIB-4 and alcohol use in HCV/HIV co-infection
Fuster et al[93], 2013 HIV-LIVE cohortFIB-42 and APRI1LDHNo association between LDH and liver fibrosis measured with FIB-4 or APRI
Lim et al[94], 2014 VACS cohortFIB-42AUDIT-C3Advanced liver fibrosis correlated with alcohol use
Kelly et al[91], 2017WIHS cohortFIB-42Average number of drinks per week, past 6 moLight/moderate drinking was not associated with accelerated fibrosis progression
Sanvisens et al[25], 2018Patients with AUD admitted for detoxificationFIB-42; APRI1; FornsPast 6 mo, daily alcohol intakePatients with HCV were two times as likely to present with advanced liver fibrosis