Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury

Figure 5 Interplay between c-MYC, MAX network transcriptional repressor, MAF bZIP transcription factor G, and nuclear factor, erythroid 2-like 2 proteins in viral infections. MAX network transcriptional repressor (MAX) directly interacts with c-MYC and MAX network transcriptional repressor proteins, while c-MYC and MAF bZIP transcription factor G (MAFG) interact with nuclear factor, erythroid 2-like 2 (NRF2). These complexes bind to E-box elements in the promoters of c-MYC and MAFG genes, regulating their activation. In addition, c-MYC and MAFG interact with NRF2, and their complexes bind to antioxidant response elements, regulating downstream gene expression. COVID-19: Coronavirus disease 2019.