Early serum albumin changes in patients with ulcerative colitis treated with tacrolimus will predict clinical outcome

Table 5 Multivariate analysis for predicting failure during 3 mo after tacrolimus induction

Variable	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Week 2/week 0 Alb ratio ≤ 1	3.632	1.396-9.445	0.008	7.195	2.011-25.74	0.002
Age	1.026	0.998-1.055	0.072	1.009	0.976-1.042	0.599
Sex (male)	2.139	0.489-9.362	0.313	2.420	0.435-13.45	0.313
Disease extent (extensive colitis)	1.062	0.243-4.640	0.937	4.665	0.554-39.30	0.157
MES 3	1.188	0.341-4.137	0.787	0.462	0.142-1.503	0.200
Medication
Oral 5-ASA	0.450	0.158-1.277	0.133	0.578	0.191-1.744	0.331
Suppository 5-ASA	0.652	0.149-2.853	0.570	0.247	0.035-1.744	0.161
Systemic steroids	0.729	0.281-1.890	0.515	0.636	0.193-2.094	0.457
Immunomodulators	1.152	0.375-3.543	0.805	1.516	0.391-5.885	0.548
Biologics	1.400	0.493-3.978	0.527	0.924	0.173-4.920	0.926

5-ASA: 5-aminosalicylic acid; Alb: Albumin; HR: Hazard ratio; MES: Mayo endoscopic subscore.