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©The Author(s) 2021.
World J Gastroenterol. Jun 14, 2021; 27(22): 3064-3072
Published online Jun 14, 2021. doi: 10.3748/wjg.v27.i22.3064
Published online Jun 14, 2021. doi: 10.3748/wjg.v27.i22.3064
Table 2 Main findings regarding the association between fatty liver disease and coronavirus disease 2019 in children
Ref. | Study design | Population | NAFLD | Main findings |
Qiu et al[36] | Cohort study. Three hospitals in Zhejiang Province, China | 36 pediatric patients (aged 0-16 yr) with laboratory confirmed COVID-19 infection; mild cases (n = 17); moderate cases (n = 19) compared with adults with COVID-19 (n = 175); Children with SARS (n = 44); Children with H1N1 influenza (n = 167) | Increased liver enzymes | Elevated ALT in two patients (mild cases) and AST in three patients (two mild and one moderate case), 6% of cases with elevated liver enzymes, 18% of cases with elevated liver enzymes, 48% of cases with elevated liver enzymes, 17% of cases with elevated liver enzymes |
Sun et al[37] | Retrospective analysis. Intensive Care Unit, Wuhan Children’s Hospital | 8 severe or critically ill COVID-19 patients admitted to the ICU. Age: 2 mo-15 yr | Increased liver enzymes | Elevated ALT levels in 4 out of 8 patients. Total bilirubin level in all patients was normal |
Wang et al[39] | Retrospective study. Children from six provinces (autonomous region) in northern China. | 31 cases of COVID-19. Age: 6 mo-17 yr | Increased liver enzymes | Elevation of liver enzyme (22%) |
Xia et al[38] | Retrospective study. Wuhan Children’s Hospital | 20 COVID-19 pediatric patients. Age: 1 d-14 yr, 7 mo (median age: 2 yr and 1.5 mo) | No NAFLD screening. CT was performed for pneumonia | Elevated ALT (> 40 U/L) in 25% of cases |
Jiehao et al[40] | Case series. Children’s Hospital in Shanghai, Hainan, Hefei in Anhui province, and Qingdao in Shandong province | 10 patients aged 3-131 mo (mean: 74 mo). Male: female 1:1.5 | No NAFLD screening. CT was performed for pneumonia | Median ALT: 18.5 U/L, AST: 27.7 U/L. One patient had ALT: 100 U/L and AST: 142 U/L |
Tan et al[41] | Retrospective study. North Hospital of Changsha First Hospital | 10 children with confirmed COVID-19 infection. Mean age of 7 yr (1-12 yr) | Increased liver enzymes | Elevated AST in two patients |
- Citation: Di Sessa A, Lanzaro F, Zarrilli S, Picone V, Guarino S, Miraglia del Giudice E, Marzuillo P. COVID-19 and pediatric fatty liver disease: Is there interplay? World J Gastroenterol 2021; 27(22): 3064-3072
- URL: https://www.wjgnet.com/1007-9327/full/v27/i22/3064.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i22.3064