Fecal microbiota transplantation for irritable bowel syndrome: An intervention for the 21st century

Table 2 Criteria of a super-donor and how the 7 published randomized clinical trials met them

Study	BMI sex	Age < 50 yr	Smoking	Vaginal delivery	Formula-fed	frequent treatment with antibiotics	regular intake of non-antibiotic drugs	regular exercise	consuming a sport-specific diet	first-degree relative	bacterial signature	stability of the bacterial composition over time
El-Salhy et al[11], 2020	Yes/male	Yes	No	Yes	No	No	No	Yes	Yes	No	YES	Yes
Johnsen et al[22], 2018	Unknown/unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown
Halkjær et al[23], 2018	Yes/unknown	Yes	Unknown	Unknown	Unknown	Unknown	No	Unknown	Unknown	Unknown	Unknown	Unknown
Aroniadis et al[24], 2019	Yes/unknown	Yes	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown
Holster et al[25], 2019	Unknown/unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown
Lahtinen et al[26], 2020	Yes/male	Yes	Unknown	Yes	Unknown	No	No	Unknown	No	Unknown	Unknown	Unknown
Holvoet et al[27], 2021	Yes/male	Yes	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Yes

BMI: Body mass index.