Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology

Figure 7 Enrichment of cytochromes P450 family members involved in drug and xenobiotics metabolism in the downregulated transcriptome of severe coronavirus disease 2019 patients liver tissues. A: Box plot representation of some of the significantly downregulated cytochrome P450 family members; B: Kegg pathway representations of the suppressive effect of severe acute respiratory syndrome coronavirus 2 infection in liver on xenobiotic and drug metabolism through cytochrome P450 and other enzymes. Data presented as mean ± SE; ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0005, ^eP < 0.0001 coronavirus disease 2019 (COVID-19) vs Healthy. CYP39A1: Cytochrome P450 family 39 subfamily A member 1; CYP11A1: Cytochrome P450 family 11 subfamily A member 1; CYP4X1: Cytochrome P450 family 4 subfamily X member 1; CYP2U1: Cytochrome P450 family 2 subfamily U member 1; CYP1A2: Cytochrome P450 family 1 subfamily A member 2.