Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology

Figure 5 Comparative analysis of the overlapping transcriptomes mapping to severe coronavirus disease 2019 liver tissue, hepatitis A, hepatitis B, and hepatitis C. A: Table representing the genes overlapping between the upregulated signature of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infected liver tissue samples and the signatures of hepatitis A, B, and C retrieved from DisGeNET; gene disease association score was retrieved from DisGeNET and fold change is calculated using AltAnalyze to represent the difference in expression in COVID-19 liver tissue samples vs non-COVID-19 liver samples; B: Top 20 pathways and functional clusters enriched in the commonly upregulated genes between SARS-CoV-2 infected liver tissues and hepatitis A, B, and C disease signatures analyzed using Metascape. GDA score: Gene disease association score; F.C.: Fold change.